Pilot Knob can refer to:
- Pilot Knob, California, Butterfield Overland Mail stage station named for the nearby Pilot Knob (Imperial County, California), and the former name of Araz, California.
- Pilot Knob, Indiana, unincorporated place
- Pilot Knob, Missouri, town
- Pilot Knob, Texas, unincorporated place
- Pilot Knob, Wisconsin, a ghost town
- One of 103 summits within the United States, including:
- Pilot Knob (Austin, Texas)
- Pilot Knob (Imperial County, California), a California mountain, southwest of Fort Yuma and Yuma, Arizona, west of the Colorado River.
- Pilot Knob (Colorado), a high mountain summit in Colorado, U.S.
- Pilot Knob (Iron County, Missouri), Iron, Missouri
- Pilot Knob State Nature Preserve, Powell County, Kentucky
- Pilot Knob Mountain, a tank gunnery range at Fort Hood, Texas
See also
- Pilot Mountain (disambiguation)
- Battle of Fort Davidson, also known as the Battle of Pilot Knob, in Missouri
