James Alexander Thomson (born December 20, 1958) is an American developmental biologist best known for deriving the first human embryonic stem cell (SC) line in 1998 and for deriving human induced pluripotent stem cells (iPS) in 2007.
Thomson's research
Human embryonic stem cells can divide without limit, and yet maintain the potential to make all the cells of the body. This remarkable potential makes them useful for basic research on the function of the human body, for drug discovery and testing, and as a source of cells and tissues for transplantation medicine. In 1998, Thomson’s Lab was the first to report the successful isolation of human embryonic stem cells. On November 6, 1998, Science published this research in an article titled "Embryonic Stem Cell Lines Derived from Human Blastocysts", results which Science later featured in its “Scientific Breakthrough of the Year†article, 1999.
In spite of their great medical potential, however, human embryonic stem cells generated enormous controversy because their derivation involved the destruction of a human embryo. In 2007, Thomson’s group (contemporaneously with Dr. Shinya Yamanaka) reported a method for converting human skin cells into cells that very closely resemble human embryonic stem cells. Published in Science in late 2007 in an article titled "Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells", the results garnered international attention for potentially ending the ethical controversy surrounding human embryonic stem cell research. Science later featured induced pluripotent stem cells in its “Scientific Breakthrough of the Year†article, 2008.
Education
Thomson graduated with a B.S. in biophysics from the University of Illinois in 1981. He entered the Veterinary Medical Scientist Training Program at the University of Pennsylvania, receiving his doctorate in veterinary medicine in 1985, and his doctorate in molecular biology in 1988. His doctoral thesis involved understanding genetic imprinting in early mammalian development under the mentorship of Davor Solter at the Wistar Institute. Thomson also spent two years (1989â€"91) as a postdoctoral research fellow in the Primate In Vitro Fertilization and Experimental Embryology Laboratory at the Oregon National Primate Research Center, and completed a residency in veterinary pathology at the University of Wisconsinâ€"Madison (1991â€"1994).
Current employment
He serves as Director of Regenerative Biology at the Morgridge Institute for Research in Madison, Wisconsin, is a professor in the Department of Cell and Regenerative Biology at the University of Wisconsin School of Medicine and Public Health and a professor in the Molecular, Cellular, and Developmental Biology Department at the University of California, Santa Barbara. He is also a founder of Cellular Dynamics International, a Madison-based company producing derivatives of human induced pluripotent stem cells for drug discovery and toxicity testing. In the mid-1990s he was recruited by Michael D. West, PhD, founder of Geron to join the company's Scientific Advisory Board, on which he no longer serves.
Awards
Thomson is a member of the National Academy of Sciences and the recipient of numerous awards and prizes. He was on the cover of TIME magazine's "America's Best in Science & Medicine" feature in 2001 for his work with human embryonic stem cells, and again in 2008 when the magazine named him one of the world's 100 most influential people for his derivation of human induced pluripotent stem cells. In 2011, Thomson was co-recipient, with Dr. Shinya Yamanaka, of the King Faisal International Prize and the Albany Medical Center Prize. In 2013, Thomson received an honorary doctor of science degree from the University of Illinois at Urbana-Champaign.
References
External links
- Morgridge Institute for Research
- Morgridge Institute for Research, Thomson Lab
- University of California, Santa Barbara - Molecular, Cellular, & Developmental Biology
- University of Wisconsin School of Medicine and Public Health
- Genome Center of Wisconsin
- Cellular Dynamics International
- Academy of Achievement Bio
- "For stem cell scientist James Thomson, discovery trumps fame", article from the University of Wisconsinâ€"Madison's alumni magazine
- "Stem cell pioneer does a reality check". MSNBC interview with James Thomson
- Nature Reports Stem Cells Q&A with James Thomson
